Cyclization of aromatic polyketides from bacteria and fungi

被引：104

作者：

Zhou, Hui ^{[1
]}

Li, Yanran ^{[1
]}

Tang, Yi ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

来源：

NATURAL PRODUCT REPORTS | 2010年 / 27卷 / 06期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

BIOSYNTHETIC GENE-CLUSTER; I FATTY-ACID; MALONYL-COENZYME-A; ENGINEERED BIOSYNTHESIS; HETEROLOGOUS EXPRESSION; SYNTHASE GENES; CRYSTAL-STRUCTURE; ENZYMATIC-SYNTHESIS; STREPTOMYCES-GLAUCESCENS; ASPERGILLUS-NIDULANS;

D O I：

10.1039/b911518h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review discusses the enzymatic basis of the different cyclization strategies used by bacteria and fungi in the biosynthesis of aromatic polyketides.

引用

页码：839 / 868

页数：30

共 205 条

[1] Structure-based engineering of a plant type III polyketide synthase: Formation of an unnatural nonaketide naphthopyrone [J].

Abe, Ikuro ;

Morita, Hiroyuki ;

Oguro, Satoshi ;

Noma, Hisashi ;

Wanibuchi, Kiyofumi ;

Kawahara, Nobuo ;

Goda, Yukihiro ;

Noguchi, Hiroshi ;

Kohno, Toshiyuki .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (18) :5976-5980

[2] Biosynthesis of phloroglucinol [J].

Achkar, J ;

Xian, M ;

Zhao, HM ;

Frost, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (15) :5332-5333

[3] The calicheamicin gene cluster and its iterative type I enediyne PKS [J].

Ahlert, J ;

Shepard, E ;

Lomovskaya, N ;

Zazopoulos, E ;

Staffa, A ;

Bachmann, BO ;

Huang, KX ;

Fonstein, L ;

Czisny, A ;

Whitwam, RE ;

Farnet, CM ;

Thorson, JS .

SCIENCE, 2002, 297 (5584) :1173-1176

[4] A CONVENIENT SYNTHESIS OF ISOTOPICALLY LABELED ANTHRAQUINONES, CHRYSOPHANOL, ISLANDICIN, AND EMODIN - INCORPORATION OF [METHYL-2H3]CHRYSOPHANOL INTO TAJIXANTHONE IN ASPERGILLUS-VARIECOLOR [J].

AHMED, SA ;

BARDSHIRI, E ;

SIMPSON, TJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (12) :883-884

[5] Structural basis for macrolactonization by the pikromycin thioesterase [J].

Akey, David L. ;

Kittendorf, Jeffrey D. ;

Giraldes, John W. ;

Fecik, Robert A. ;

Sherman, David H. ;

Smith, Janet L. .

NATURE CHEMICAL BIOLOGY, 2006, 2 (10) :537-542

[6] Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides [J].

Ames, Brian Douglas ;

Korman, Tyler Paz ;

Zhang, Wenjun ;

Smith, Peter ;

Vu, Thanh ;

Tang, Yi ;

Tsai, Shiou-Chuan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (14) :5349-5354

[7]

ARSENAULT GP, 1965, TETRAHEDRON LETT, P4033

[8] Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates [J].

Austin, MB ;

Izumikawa, M ;

Bowman, ME ;

Udwary, DW ;

Ferrer, JL ;

Moore, BS ;

Noel, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (43) :45162-45174

[9] The chalcone synthase superfamily of type III polyketide synthases [J].

Austin, MB ;

Noel, JP .

NATURAL PRODUCT REPORTS, 2003, 20 (01) :79-110

[10] Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid -: type III polyketide synthase [J].

Austin, Michael B. ;

Saito, Tamao ;

Bowman, Marianne E. ;

Haydock, Stephen ;

Kato, Atsushi ;

Moore, Bradley S. ;

Kay, Robert R. ;

Noel, Joseph P. .

NATURE CHEMICAL BIOLOGY, 2006, 2 (09) :494-502

← 1 2 3 4 5 6 7 8 9 10 →