Enantioselective hydrogenation of (E)-α-phenylcinnamic acid on Pd/TiO2 catalyst modified by cinchona alkaloids:: Effect of modifier structure

被引：76

作者：

Nitta, Y ^{[1
]}

Shibata, A ^{[1
]}

机构：

[1] Niihama Natl Coll Technol, Niihama, Ehime 792, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 02期

关键词：

D O I：

10.1246/cl.1998.161

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of modifier structure on enantioselectivity and activity in the hydrogenation of (E)-alpha-phenylcinnamic acid with cinchona-modified Pd/TiO2 catalyst has been found to be in contrast to the hydrogenation of alpha-ketoesters with modified platinum catalysts. It is suggested that the interaction of the hydroxyl group at C9 of cinchonidine with the carboxyl group in the substrate is crucial to induce a high enantioselectivity.

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页码：161 / 162

页数：2

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