IL-17 Signaling: The Yin and the Yang

被引：854

作者：

Amatya, Nilesh ^{[1
]}

Garg, Abhishek V. ^{[1
]}

Gaffen, Sarah L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

来源：

TRENDS IN IMMUNOLOGY | 2017年 / 38卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CHRONIC MUCOCUTANEOUS CANDIDIASIS; NF-KAPPA-B; MESSENGER-RNA STABILIZATION; INTERLEUKIN; 17; RECEPTOR; LIGAND-BINDING SITE; AUTOIMMUNE INFLAMMATION; CROHNS-DISEASE; T-CELL; PLAQUE PSORIASIS; GENE-EXPRESSION;

D O I：

10.1016/j.it.2017.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progression. In this review we discuss both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events. We highlight the surprisingly diverse means by which these regulators control expression of IL-17-dependent inflammatory genes, as well as the major target cells that respond to IL-17 signaling.

引用

页码：310 / 322

页数：13

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