IL-17 Signaling: The Yin and the Yang

被引：854

作者：

Amatya, Nilesh ^{[1
]}

Garg, Abhishek V. ^{[1
]}

Gaffen, Sarah L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Div Rheumatol & Clin Immunol, Pittsburgh, PA 15261 USA

来源：

TRENDS IN IMMUNOLOGY | 2017年 / 38卷 / 05期

基金：

美国国家卫生研究院;

关键词：

CHRONIC MUCOCUTANEOUS CANDIDIASIS; NF-KAPPA-B; MESSENGER-RNA STABILIZATION; INTERLEUKIN; 17; RECEPTOR; LIGAND-BINDING SITE; AUTOIMMUNE INFLAMMATION; CROHNS-DISEASE; T-CELL; PLAQUE PSORIASIS; GENE-EXPRESSION;

D O I：

10.1016/j.it.2017.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the proinflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progression. In this review we discuss both the activators and the inhibitors of IL-17 signal transduction, and also the physiological implications of these events. We highlight the surprisingly diverse means by which these regulators control expression of IL-17-dependent inflammatory genes, as well as the major target cells that respond to IL-17 signaling.

引用

收藏

页码：310 / 322

页数：13

相关论文

共 104 条

[71]

TRAF6-Dependent Act1 Phosphorylation by the IκB Kinase-Related Kinases Suppresses Interleukin-17-Induced NF-κB Activation [J].

Qu, Fangfang ;

Gao, Hanchao ;

Zhu, Shu ;

Shi, Peiqing ;

Zhang, Yifan ;

Liu, Yan ;

Jallal, Bahija ;

Yao, Yihong ;

Shi, Yufang ;

Qian, Youcun .

MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (19) :3925-3937

[72]

The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney [J].

Ramani, Kritika ;

Garg, Abhishek V. ;

Jawale, Chetan V. ;

Conti, Heather R. ;

Whibley, Natasha ;

Jackson, Edwin K. ;

Shiva, Sruti S. ;

Horne, William ;

Kolls, Jay K. ;

Gaffen, Sarah L. ;

Biswas, Partha S. .

PLOS PATHOGENS, 2016, 12 (11)

[73]

CCAAT/enhancer-binding proteins: Structure, function and regulation [J].

Ramji, Dipak P. ;

Foka, Pelagia .

Biochemical Journal, 2002, 365 (03) :561-575

[74]

ROUVIER E, 1993, J IMMUNOL, V150, P5445

[75]

Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment [J].

Ruddy, MJ ;

Shen, F ;

Smith, JB ;

Sharma, A ;

Gaffen, SL .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (01) :135-144

[76]

Functional cooperation between interleukin-17 and tumor necrosis factor-α is mediated by CCAAT/enhancer-binding protein family members [J].

Ruddy, MJ ;

Wong, GC ;

Liu, XKK ;

Yamamoto, H ;

Kasayama, S ;

Kirkwood, KL ;

Gaffen, SL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (04) :2559-2567

[77]

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease [J].

Sandborn, William J. ;

Gasink, Christopher ;

Gao, Long-Long ;

Blank, Marion A. ;

Johanns, Jewel ;

Guzzo, Cynthia ;

Sands, Bruce E. ;

Hanauer, Stephen B. ;

Targan, Stephan ;

Rutgeerts, Paul ;

Ghosh, Subrata ;

de Villiers, Willem J. S. ;

Panaccione, Remo ;

Greenberg, Gordon ;

Schreiber, Stefan ;

Lichtiger, Simon ;

Feagan, Brian G. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (16) :1519-1528

[78]

Secukinumab: First Global Approval [J].

Sanford, Mark ;

McKeage, Kate .

DRUGS, 2015, 75 (03) :329-338

[79]

Saunte D. M., 2016, BR J DERMATOL

[80]

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction [J].

Schwandner, R ;

Yamaguchi, K ;

Cao, ZD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (07) :1233-1239

← 2 3 4 5 6 7 8 9 10 11 →