Synthesis and antineoplastic activity of cyclolignan aldehydes

被引：23

作者：

Gordaliza, M ^{[1
]}

Castro, A

del Corral, JM

López-Vázquez, L

García, PA

García-Grávalos, D

San Feliciano, A

机构：

[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain

[2] Biomar SA, E-28760 Madrid, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 35卷 / 7-8期

关键词：

cyclolignan aldehydes; non-lactonic derivatives; podophyllotoxin; selective cytotoxicity;

D O I：

10.1016/S0223-5234(00)00176-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several aldehydes related to methyl 9-deoxy-9-oxo-alpha-apopicropodophyllate, a selective antitumour agent against the HT-29 colon carcinoma, have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the mu M level. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：691 / 698

页数：8

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