Palladium-catalyzed 2-pyridylmethyl transfer from 2-(2-pyridyl)-ethanol derivatives to organic halides by chelation-assisted cleavage of unstrained Csp3-Csp3 bonds

被引：108

作者：

Niwa, Takashi ^{[1
]}

Yorimitsu, Hideki ^{[1
]}

Oshima, Koichiro ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 15期

关键词：

azaarenes; C-C activation; cross-coupling; homogeneous catalysis; palladium;

D O I：

10.1002/anie.200604472

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Making a break for it: Treatment of 2-(2-pyridyl)ethanol derivatives with aryl chlorides in the presence of a palladium catalyst results in the transfer of the pyridylmethyl moiety of the alcohol to yield the corresponding (2-pyridyl-methyl)arene. The reaction proceeds by chelation-assisted cleavage of an Csp3-C5p3 bond (see scheme) followed by formation of a carbon-carbon bond. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2643 / 2645

页数：3

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