Gene segment selection in V(D)J recombination: accessibility and beyond

被引：139

作者：

Krangel, MS ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/ni0703-624

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency and specificity in ways that had not been previously appreciated. Recent developments have increased our understanding of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.

引用

页码：624 / 630

页数：7

共 95 条

[1] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].

Agalioti, T ;

Lomvardas, S ;

Parekh, B ;

Yie, JM ;

Maniatis, T ;

Thanos, D .

CELL, 2000, 103 (04) :667-678

[2] Histone acetylation determines the developmentally regulated accessibility for T cell receptor γ gene recombination [J].

Agata, Y ;

Katakai, T ;

Ye, SK ;

Sugai, M ;

Gonda, H ;

Honjo, T ;

Ikuta, K ;

Shimizu, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (07) :873-879

[3] Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment [J].

Angelin-Duclos, C ;

Calame, K .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6253-6264

[4] Developmentally programmed rearrangement of T cell receptor Vγ genes is controlled by sequences immediately upstream of the Vγ genes [J].

Baker, JE ;

Cado, D ;

Raulet, DH .

IMMUNITY, 1998, 9 (02) :159-168

[5] Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule [J].

Bassing, CH ;

Alt, FW ;

Hughes, MM ;

D'Auteuil, M ;

Wehrly, TD ;

Woodman, BB ;

Gärtner, F ;

White, JM ;

Davidson, L ;

Sleckman, BP .

NATURE, 2000, 405 (6786) :583-586

[6] The mechanism and regulation of chromosomal V(D)J recombination [J].

Bassing, CH ;

Swat, W ;

Alt, FW .

CELL, 2002, 109 :S45-S55

[7] Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility [J].

Bories, JC ;

Demengeot, J ;

Davidson, L ;

Alt, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7871-7876

[8] Deletion of the mouse T-cell receptor beta gene enhancer blocks alpha beta T-cell development [J].

Bouvier, G ;

Watrin, F ;

Naspetti, M ;

Verthuy, C ;

Naquet, P ;

Ferrier, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7877-7881

[9] ChIPs of the β-globin locus:: unraveling gene regulation within an active domain [J].

Bulger, M ;

Sawado, T ;

Schübeler, D ;

Groudine, M .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) :170-177

[10] TCR-BETA AND TCR-ALPHA GENE ENHANCERS CONFER TISSUE-SPECIFICITY AND STAGE-SPECIFICITY ON V(D)J RECOMBINATION EVENTS [J].

CAPONE, M ;

WATRIN, F ;

FERNEX, C ;

HORVAT, B ;

KRIPPL, B ;

WU, L ;

SCOLLAY, R ;

FERRIER, P .

EMBO JOURNAL, 1993, 12 (11) :4335-4346

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