Gene segment selection in V(D)J recombination: accessibility and beyond

被引：142

作者：

Krangel, MS ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/ni0703-624

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency and specificity in ways that had not been previously appreciated. Recent developments have increased our understanding of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.

引用

页码：624 / 630

页数：7

共 95 条

[21] THE BASIS FOR THE MECHANISTIC BIAS FOR DELETIONAL OVER INVERSIONAL V(D)J RECOMBINATION [J].

GAUSS, GH ;

LIEBER, MR .

GENES & DEVELOPMENT, 1992, 6 (08) :1553-1561

[22] Replication timing and transcriptional control: beyond cause and effect [J].

Gilbert, DM .

CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (03) :377-383

[23] Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase [J].

Golding, A ;

Chandler, S ;

Ballestar, E ;

Wolffe, AP ;

Schlissel, MS .

EMBO JOURNAL, 1999, 18 (13) :3712-3723

[24] Differential accessibility at the κ chain locus plays a role in allelic exclusion [J].

Goldmit, M ;

Schlissel, M ;

Cedar, H ;

Bergman, Y .

EMBO JOURNAL, 2002, 21 (19) :5255-5261

[25] Replicating by the clock [J].

Goren, A ;

Cedar, H .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (01) :25-32

[26] Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus [J].

Gribnau, J ;

Diderich, K ;

Pruzina, S ;

Calzolari, R ;

Fraser, P .

MOLECULAR CELL, 2000, 5 (02) :377-386

[27] Regulation of the TCRα repertoire by the survival window of CD4+CD8+ thymocytes [J].

Guo, J ;

Hawwari, A ;

Li, H ;

Sun, ZM ;

Mahanta, SK ;

Littman, DR ;

Krangel, MMS ;

He, YW .

NATURE IMMUNOLOGY, 2002, 3 (05) :469-476

[28] Enhancer control of V(D)J recombination at the TCRβ locus:: differential effects on DNA cleavage and joining [J].

Hempel, WM ;

Stanhope-Baker, P ;

Mathieu, N ;

Huang, F ;

Schlissel, MS ;

Ferrier, P .

GENES & DEVELOPMENT, 1998, 12 (15) :2305-2317

[29] A developmental switch from TCRδ enhancer to TCRα enhancer function during thymocyte maturation [J].

Hernández-Munain, C ;

Sleckman, BP ;

Krangel, MS .

IMMUNITY, 1999, 10 (06) :723-733

[30] Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments [J].

Hesslein, DGT ;

Pflugh, DL ;

Chowdhury, D ;

Bothwell, ALM ;

Sen, RJ ;

Schatz, DG .

GENES & DEVELOPMENT, 2003, 17 (01) :37-42

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