Bioactivities of black cumin essential oil and its main terpenes from Tunisia

被引：131

作者：

Bourgou, S. ^{[1
]}

Pichette, A. ^{[2
]}

Marzouk, B. ^{[1
]}

Legault, J. ^{[2
]}

机构：

[1] Ctr Biotechnol, Unite Plantes Aromat & Med, Hammam Lif, Tunisia

[2] Univ Quebec Chicoutimi, Dept Sci Fondamentales, Lab Anal & Separat Essences Vegetales, Chicoutimi, PQ G7H 2B1, Canada

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2010年 / 76卷 / 02期

关键词：

Antibacterial; Anticancer; Anti-inflammatory; Antioxidant; Essential oil; Nigella saliva L; Terpenes; NIGELLA-SATIVA L; NITRIC-OXIDE SYNTHASE; CHEMICAL-COMPOSITION; ANTIOXIDANT ACTIVITY; ALPHA-HEDERIN; THYMOQUINONE; EXPRESSION; PRINCIPLE; EXTRACT; SEEDS;

D O I：

10.1016/j.sajb.2009.10.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ex vivo antioxidant, anti-inflammatory, anticancer and antibacterial activities of the essential oil from Tunisian Nigella saliva seeds and its main terpenes (p-cymene, gamma-terpinene, thymoquinone, beta-pinene, carvacrol, terpinen-4-ol and longifolene) were determined. The essential oil exhibited strong ex vivo antioxidant activity, inhibiting DCFH oxidation with an IC50 of 1.0 mu g/ml, and high anti-inflammatory activity, inhibiting NO radical excretion with an IC50 value of 6.3 mu g/ml. Thymoquinone was found to be the most active to decrease DCFH oxidation and NO excretion. The oil was found to significantly inhibit the growth of A-549 and DLD-1 cancer cell lines (IC50 values of 43.0 and 46.0 mu g/ml, respectively) and to exert antibacterial activity against Staphylococcus aureus and Escherichia coli with IC50 values of 12.0 and 62.0 mu g/ml. The anticancer and antibacterial activities could be mainly due to the action of thymoquinone and longifolene. (C) 2009 SAAB. Published by Elsevier B.V. All rights reserved.

引用

页码：210 / 216

页数：7

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