Distribution of ventilation in lung transplant recipients:: Evaluation by dynamic 3He-MRI with lung motion correction

Rationale and objectives. The ability of motion corrected dynamic 3 He-magnetic resonance imaging (MRI) to discriminate distributional patterns of inhaled hyperpolarized He-3 between different groups of lung transplant recipients was evaluated. Methods: An ultrafast low-angle shot 2D sequence (temporal resolution 128 ms) was used for ventilation He-3-MRI of 11 single and 6 double lung transplant recipients. After digital motion correction, signal kinetics were evaluated in a tracheal and 7 pulmonary regions of interest. Results from grafts and native lungs as well as from normal and rejected grafts were compared with each other and to reference values from healthy subjects. Results: In emphysema patients, median alveolar rise time, a parameter for increase of alveolar signal, was 0.28 seconds for the graft and 0.48 seconds for the native lung, in fibrosis patients its median was 0.46 seconds for the graft and 0.21 seconds for the native lung. In double lung recipients, alveolar rise time was 0.29 seconds in normal and clinically rejected grafts. Conclusions: Dynamic ventilation He-3-MRI discriminated normal lung grafts from diseased native lungs in single lung recipients. Graft rejection in double lung recipients could not be discriminated.