Echinacea purpurea aerial extract alters course of influenza infection in mice

被引：34

作者：

Fusco, Dahlene ^{[2
]}

Liu, Xinyan ^{[1
]}

Savage, Caroline ^{[3
]}

Taur, Ying ^{[1
]}

Xiao, Weilie ^{[5
]}

Kennelly, Edward ^{[5
]}

Yuan, Jianda ^{[6
]}

Cassileth, Barrie ^{[7
]}

Salvatore, Mirella ^{[2
,4
]}

Papanicolaou, Genovefa A. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Infect Dis Serv, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Div Infect Dis, New York, NY USA

[3] Mem Sloan Kettering Canc Ctr, Dept Biostat, New York, NY 10065 USA

[4] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY USA

[5] Lehman Coll, Dept Biol Sci, New York, NY USA

[6] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, New York, NY USA

[7] Mem Sloan Kettering Canc Ctr, Integrat Med Serv, New York, NY USA

来源：

VACCINE | 2010年 / 28卷 / 23期

关键词：

Influenza; Echinacea; Cytokines; Mice; VIRUS H5N1; ANGUSTIFOLIA; PNEUMONIA; IL-10;

D O I：

10.1016/j.vaccine.2010.03.047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-gamma levels following influenza infection. These suggest that E. purpurea alters the clinical course of influenza infection in mice through modulation of cytokines and not direct antiviral activity. (C) 2010 Published by Elsevier Ltd.

引用

页码：3956 / 3962

页数：7

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