Synthesis of a 24-membered cyclic peptide-biphenyl hybrid

被引：17

作者：

Montero, Ana

Albericio, Fernando

Royo, Miriam

Herradon, Bernardo

机构：

[1] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

[2] Univ Barcelona, Combinatorial Chem Unit, E-08028 Barcelona, Spain

[3] Univ Barcelona, Inst Res Biomed, E-08028 Barcelona, Spain

[4] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 08期

关键词：

biaryls; calpain inhibitors; macrocycles; peptide-biphenyl hybrids; solid-phase synthesis;

D O I：

10.1002/ejoc.200600833

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a 24-membered macrocyclic peptide-biphenyl hybrid with four amino acid residues and two biphenyl fragments was performed by a combination of solid-phase and solution methodologies. The acyclic precursor was prepared by a solid phase methodology whereas the final macrocyclization was carried out by diisopropylcarbodiimide (DIPCDI) and N-hydroxybenzotriazole (HOBt) in solution. The target molecule was a moderate inhibitor of p-calpain. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).

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页码：1301 / 1308

页数：8

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