Cytotoxic, apoptotic and antioxidant activity of the essential oil of Amomum tsao-ko

被引：125

作者：

Yang Yang ^{[1
,2
]}

Yang Yue ^{[2
]}

Yan Runwei ^{[1
]}

Zou Guolin ^{[1
]}

机构：

[1] Wuhan Univ, State Key Lab Virol, Coll Life Sci, Ctr Nanosci & Nanotechnol, Wuhan 430072, Peoples R China

[2] Guilin Med Coll, Coll Pharm, Guilin 541004, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2010年 / 101卷 / 11期

关键词：

Amomum tsao-ko; Essential oil; Cytotoxicity; Apoptosis; Antioxidant; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; CONSTITUENTS; GERANIOL; GROWTH; CANCER; BIOSYNTHESIS; CELLS;

D O I：

10.1016/j.biortech.2009.12.131

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

The antioxidant activity, cytotoxicity and mechanism of induction of HepG2 cell death of essential oil from Amomum tsao-ko were determined. The essential oil was cytotoxic to HepG2, Hela, Bel-7402, SGC-7901 and PC-3 cell lines. The lowest IC50 of 31.80 +/- 1.181 mu g/ml was measured for HepG2 carcinoma cell lines. The IC50 for normal human cell lines (HUVEC and HL-7702) was 163.91 +/- 5.11-272.41 +/- 0.97 mu g/ml. Analyses by flow cytometry. Hoechst 33258 staining and agarose gel electrophoresis indicated that the essential oil induced apoptosis. The essential oil has weak antioxidant activity as measured by 1,1-dipheny1-2-picrylhydrazyl (DPPH) radical assay, thiobarbituric acid (TBA) test and ferric reducing antioxidant power (FRAP) assay. The data suggest that the essential oil of A. tsao-ko could be a potential medicinal resource. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4205 / 4211

页数：7

共 32 条

[1]

Adam R.P., 2001, Identification of essential oil components by gas chromatography/quadrupole mass spectroscopy

[2] CHELATING AND FREE-RADICAL SCAVENGING MECHANISMS OF INHIBITORY-ACTION OF RUTIN AND QUERCETIN IN LIPID-PEROXIDATION [J].

AFANASEV, IB ;

DOROZHKO, AI ;

BRODSKII, AV ;

KOSTYUK, VA ;

POTAPOVITCH, AI .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) :1763-1769

[3] Biological effects of essential oils - A review [J].

Bakkali, F. ;

Averbeck, S. ;

Averbeck, D. ;

Waomar, M. .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) :446-475

[4] Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol [J].

Burke, YD ;

Stark, MJ ;

Roach, SL ;

Sen, SE ;

Crowell, PL .

LIPIDS, 1997, 32 (02) :151-156

[5] Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer [J].

Cai, YZ ;

Luo, Q ;

Sun, M ;

Corke, H .

LIFE SCIENCES, 2004, 74 (17) :2157-2184

[6]

Carnesecchi S, 2001, J PHARMACOL EXP THER, V298, P197

[7] Iridoid glucosides with free radical scavenging properties from Fagraea blumei [J].

Cuendet, M ;

Hostettmann, K ;

Potterat, O ;

Dyatmiko, W .

HELVETICA CHIMICA ACTA, 1997, 80 (04) :1144-1152

[8] Chemopreventive effects of dietary mustard oil on colon tumor development [J].

Dwivedi, C ;

Muller, LA ;

Goetz-Parten, DE ;

Kasperson, K ;

Mistry, VV .

CANCER LETTERS, 2003, 196 (01) :29-34

[9] Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: A review [J].

Edris, Amr E. .

PHYTOTHERAPY RESEARCH, 2007, 21 (04) :308-323

[10] Chemical composition, cytotoxic and antioxidant activity of the leaf essential oil of Photinia serrulata [J].

Hou Jie ;

Sun Tao ;

Hu Jun ;

Chen Shuangyang ;

Cai Xiaoqiang ;

Zou Guolin .

FOOD CHEMISTRY, 2007, 103 (02) :355-358

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