Cytotoxic, apoptotic and antioxidant activity of the essential oil of Amomum tsao-ko

被引：125

作者：

Yang Yang ^{[1
,2
]}

Yang Yue ^{[2
]}

Yan Runwei ^{[1
]}

Zou Guolin ^{[1
]}

机构：

[1] Wuhan Univ, State Key Lab Virol, Coll Life Sci, Ctr Nanosci & Nanotechnol, Wuhan 430072, Peoples R China

[2] Guilin Med Coll, Coll Pharm, Guilin 541004, Peoples R China

来源：

BIORESOURCE TECHNOLOGY | 2010年 / 101卷 / 11期

关键词：

Amomum tsao-ko; Essential oil; Cytotoxicity; Apoptosis; Antioxidant; ANTIMICROBIAL ACTIVITY; CHEMICAL-COMPOSITION; CONSTITUENTS; GERANIOL; GROWTH; CANCER; BIOSYNTHESIS; CELLS;

D O I：

10.1016/j.biortech.2009.12.131

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

The antioxidant activity, cytotoxicity and mechanism of induction of HepG2 cell death of essential oil from Amomum tsao-ko were determined. The essential oil was cytotoxic to HepG2, Hela, Bel-7402, SGC-7901 and PC-3 cell lines. The lowest IC50 of 31.80 +/- 1.181 mu g/ml was measured for HepG2 carcinoma cell lines. The IC50 for normal human cell lines (HUVEC and HL-7702) was 163.91 +/- 5.11-272.41 +/- 0.97 mu g/ml. Analyses by flow cytometry. Hoechst 33258 staining and agarose gel electrophoresis indicated that the essential oil induced apoptosis. The essential oil has weak antioxidant activity as measured by 1,1-dipheny1-2-picrylhydrazyl (DPPH) radical assay, thiobarbituric acid (TBA) test and ferric reducing antioxidant power (FRAP) assay. The data suggest that the essential oil of A. tsao-ko could be a potential medicinal resource. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4205 / 4211

页数：7

共 32 条

[11]

*JIANGS NEW MED CO, 1977, DICT CHIN MAT MED, P1574

[12] Composition, cytotoxicity and antimicrobial activity of essential oil from Dictamnus dasycarpus [J].

Lei, Jiachuan ;

Yu, Jianqing ;

Yu, Huaidong ;

Liao, Zhixiong .

FOOD CHEMISTRY, 2008, 107 (03) :1205-1209

[13]

LI W, 1999, WORLD CHINESE J DIGE, V7, P89

[14] Antioxidant activities of phenolic, proanthocyanidin, and flavonoid components in extracts of Cassia fistula [J].

Luximon-Ramma, A ;

Bahorun, T ;

Soobrattee, MA ;

Aruoma, OI .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (18) :5042-5047

[15]

MA YS, 2006, YUNNAN J TRADIT CHIN, V27, P40

[16] Constituents of Amomum tsao-ko and their radical scavenging and antioxidant activities [J].

Martin, TS ;

Kikuzaki, H ;

Hisamoto, M ;

Nakatani, N .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 2000, 77 (06) :667-673

[17]

Moon SS, 2005, B KOR CHEM SOC, V26, P447

[18] Isotsaokoin, an antifungal agent from Amomum tsao-ko [J].

Moon, SS ;

Lee, JY ;

Cho, SC .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (05) :889-891

[19]

Owen R W, 2000, Lancet Oncol, V1, P107, DOI 10.1016/S1470-2045(00)00015-2

[20]

PLUMB JA, 1989, CANCER RES, V49, P4435

← 1 2 3 4 →