Chitosan Modification and Pharmaceutical/Biomedical Applications

被引：378

作者：

Zhang, Jiali ^{[1
,2
]}

Xia, Wenshui ^{[1
,3
]}

Liu, Ping ^{[4
]}

Cheng, Qinyuan ^{[1
,3
]}

Tahirou, Talba ^{[1
,3
]}

Gu, Wenxiu ^{[5
]}

Li, Bo ^{[1
,3
]}

机构：

[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[2] Jiangnan Univ, Sch Med & Pharmaceut, Wuxi 214122, Jiangsu, Peoples R China

[3] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

[4] Jiangsu Anim Husb & Vet Coll, Taizhou 225300, Jiangsu, Peoples R China

[5] Jiangnan Univ, Sch Chem Engn, Wuxi 214122, Jiangsu, Peoples R China

来源：

MARINE DRUGS | 2010年 / 8卷 / 07期

关键词：

chitosan derivatives; hypocholesterolemic; immunoenhancing; homeostasis; D-Glucosaminic Acid; BETA-D-GLUCOSAMINIDASE; ASPERGILLUS SP CJ22-326; N-ACETYL CHITOHEXAOSE; PHOTOCROSSLINKABLE CHITOSAN; MOLECULAR-WEIGHT; IN-VITRO; PHYSICOCHEMICAL PROPERTIES; ANTIBACTERIAL ACTIVITY; SURGICAL APPLICATIONS; ENZYMATIC PREPARATION;

D O I：

10.3390/md8071962

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand-D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and diabetes therapy.

引用

页码：1962 / 1987

页数：26

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