The epicardium signals the way towards heart regeneration

被引：82

作者：

Masters, Megan ^{[1
]}

Riley, Paul R. ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England

来源：

STEM CELL RESEARCH | 2014年 / 13卷 / 03期

关键词：

THYMOSIN BETA 4; ADULT MAMMALIAN HEART; MYOCARDIAL-INFARCTION; CARDIAC REGENERATION; RETINOIC ACID; CARDIOMYOCYTE PROLIFERATION; CORONARY-ARTERIES; EMBRYONIC DEVELOPMENT; PERICARDIAL MESODERM; VENTRICULAR-FUNCTION;

D O I：

10.1016/j.scr.2014.04.007

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

From historical studies of developing chick hearts to recent advances in regenerative injury models, the epicardium has arisen as a key player in heart genesis and repair. The epicardium provides paracrine signals to nurture growth of the developing heart from mid-gestation, and epicardium-derived cells act as progenitors of numerous cardiac cell types. Interference with either process is terminal for heart development and embryogenesis. In adulthood, the dormant epicardium reinstates an embryonic gene programme in response to injury. Furthermore, injury-induced epicardial signalling is essential for heart regeneration in zebrafish. Given these critical roles in development, injury response and heart regeneration, the application of epicardial signals following adult heart injury could offer therapeutic strategies for the treatment of ischaemic heart disease and heart failure. (C) 2014 The Authors. Published by Elsevier B.V.

引用

页码：683 / 692

页数：10

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