Application of MALDI Mass Spectrometry in Natural Products Analysis

被引：28

作者：

Silva, Ricardo ^{[1
]}

Lopes, Norberto Peporine ^{[1
]}

Silva, Denise Brentan ^{[1
,2
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, NPPNS, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Fed Mato Grosso Sul UFMS, CCBS, Lab Prod Nat & Espectrometria Massas LAPNEM, Ave Costa & Silva S-N, BR-79070900 Campo Grande, MS, Brazil

来源：

PLANTA MEDICA | 2016年 / 82卷 / 08期

关键词：

MALDI; dereplication; natural products; fragmentation; data processing; LASER-DESORPTION/IONIZATION-TIME; POST-SOURCE-DECAY; TOF MS ANALYSIS; DESORPTION IONIZATION MALDI; THIN-LAYER-CHROMATOGRAPHY; FATTY-ACID ESTERS; ARABIDOPSIS-THALIANA; SMALL MOLECULES; QUANTITATIVE-ANALYSIS; HYDROLYZABLE TANNINS;

D O I：

10.1055/s-0042-104800

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This article presents the utility of mass spectrometry with a MALDI ionization source in natural products analysis. The advantages and drawbacks of this technique for natural products analyses will be presented and discussed. In addition, the structural determination of secondary metabolites using MALDI-MS/MS will be explored, which can guide MALDI experimental methods and stimulate new research in this area. Finally, several important approaches for MALDI data processing will be discussed.

引用

页码：671 / 689

页数：19

共 235 条

[1]

AAMODT A, 1994, AI COMMUN, V7, P39

[2] Rapid quantitation of potato glycoalkaloids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [J].

Abell, DC ;

Sporns, P .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, 44 (08) :2292-2296

[3] MALDI imaging mass spectrometry: statistical data analysis and current computational challenges [J].

Alexandrov, Theodore .

BMC BIOINFORMATICS, 2012, 13

[4] Efficient spatial segmentation of large imaging mass spectrometry datasets with spatially aware clustering [J].

Alexandrov, Theodore ;

Kobarg, Jan Hendrik .

BIOINFORMATICS, 2011, 27 (13) :I230-I238

[5] Flavonoid - matrix cluster ions in MALDI mass spectrometry [J].

Amorim Madeira, Paulo J. ;

Florencio, M. Helena .

JOURNAL OF MASS SPECTROMETRY, 2009, 44 (07) :1105-1113

[6] MALDI-MS Imaging Analysis of Fungicide Residue Distributions on Wheat Leaf Surfaces [J].

Annangudi, Suresh P. ;

Myung, Kyung ;

Adame, Cruz Avila ;

Gilbert, Jeffrey R. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2015, 49 (09) :5579-5583

[7]

[Anonymous], 2010, R LANG ENV STAT COMP

[8]

[Anonymous], NEUROPROTEOMICS

[9] Metabolonote: a wiki-based database for managing hierarchical metadata of metabolome analyses [J].

Ara, Takeshi ;

Enomoto, Mitsuo ;

Arita, Masanori ;

Ikeda, Chiaki ;

Kera, Kota ;

Yamada, Manabu ;

Nishioka, Takaaki ;

Ikeda, Tasuku ;

Nihei, Yoshito ;

Shibata, Daisuke ;

Kanaya, Shigehiko ;

Sakurai, Nozomu .

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2015, 3

[10] Mass Spectrometry Imaging: An Expeditious and Powerful Technique for Fast in Situ Lignin Assessment in Eucalyptus [J].

Araujo, Pedro ;

Ferreira, Monica Siqueira ;

de Oliyeira, Diogo Noin ;

Pereira, Luciano ;

Sawaya, Alexandra Christine Helena Frank Land ;

Catharino, Rodrigo Ramos ;

Mazzafera, Paulo .

ANALYTICAL CHEMISTRY, 2014, 86 (07) :3415-3419

← 1 2 3 4 5 6 7 8 9 10 →