Infection trains the host for microbiota-enhanced resistance to pathogens

被引：200

作者：

Stacy, Apollo ^{[1
,2
,3
]}

Andrade-Oliveira, Vinicius ^{[1
,7
]}

McCulloch, John A. ^{[4
]}

Hild, Benedikt ^{[5
]}

Oh, Ji Hoon ^{[5
]}

Perez-Chaparro, P. Juliana ^{[2
]}

Sim, Choon K. ^{[6
,8
]}

Lim, Ai Ing ^{[1
]}

Link, Verena M. ^{[1
]}

Enamorado, Michel ^{[1
]}

Trinchieri, Giorgio ^{[4
]}

Segre, Julia A. ^{[6
]}

Rehermann, Barbara ^{[5
]}

Belkaid, Yasmine ^{[1
,2
]}

机构：

[1] NIAID, Metaorganism Immun Sect, Lab Host Immun & Microbiome, NIH, Bethesda, MD 20892 USA

[2] NIAID, Microbiome Program, NIH, Bethesda, MD 20892 USA

[3] Natl Inst Gen Med Sci, Postdoctoral Res Associate Training Program, NIH, Bethesda, MD 20892 USA

[4] NCI, Lab Integrat Canc Immunol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[5] NIDDK, Immunol Sect, Liver Dis Branch, NIH, Bethesda, MD 20892 USA

[6] NHGRI, Microbial Genom Sect, Translat & Funct Genom Branch, NIH, Bethesda, MD 20892 USA

[7] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Santo Andre, SP, Brazil

[8] Singapore Inst Clin Sci, Agcy Sci Technol & Res A STAR, Singapore, Singapore

来源：

CELL | 2021年 / 184卷 / 03期

关键词：

COLONIZATION RESISTANCE; GUT MICROBIOTA; METABOLISM; RESPONSES; RESERVOIR; TAURINE; FITNESS; MODEL; SHAPE;

D O I：

10.1016/j.cell.2020.12.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The microbiota shields the host against infections in a process known as colonization resistance. How infections themselves shape this fundamental process remains largely unknown. Here, we show that gut microbiota from previously infected hosts display enhanced resistance to infection. This long-term functional remodeling is associated with altered bile acid metabolism leading to the expansion of taxa that utilize the sulfonic acid taurine. Notably, supplying exogenous taurine alone is sufficient to induce this alteration in microbiota function and enhance resistance. Mechanistically, taurine potentiates the microbiota's production of sulfide, an inhibitor of cellular respiration, which is key to host invasion by numerous pathogens. As such, pharmaceutical sequestration of sulfide perturbs the microbiota's composition and promotes pathogen invasion. Together, this work reveals a process by which the host, triggered by infection, can deploy taurine as a nutrient to nourish and train the microbiota, promoting its resistance to subsequent infection.

引用

页码：615 / +

页数：30

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