Comparative in vitro activity of telithromycin (HMR 3647), three macrolides, amoxycillin, cefdinir and levofloxacin against Gram-positive clinical isolates in Japan

被引：21

作者：

Okamoto, H ^{[1
]}

Miyazaki, S ^{[1
]}

Tateda, K ^{[1
]}

Ishii, Y ^{[1
]}

Yamaguchi, K ^{[1
]}

机构：

[1] Toho Univ, Sch Med, Dept Microbiol, Ota Ku, Tokyo, Japan

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2000年 / 46卷 / 05期

关键词：

D O I：

10.1093/jac/46.5.797

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in vitro activities (MIC and MBC) of telithromycin (HMR 3647) against clinical isolates in Japan were investigated in comparison with those of erythromycin A, clarithromycin, azithromycin, amoxyciliin, cefdinir and levofloxacin, Telithromycin was more potent than the reference compounds against erythromycin A-susceptible or resistant Streptococcus pneumoniae isolates possessing either mef (mefA or mefE) genes or the ermB gene, Against erythromycin A-susceptible or inducibly resistant Staphylococcus aureus and erythromycin A-susceptible and intermediate Enterococcus faecalis, telithromycin was highly active.

引用

页码：797 / 802

页数：6

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