Building centromeres: home sweet home or a nomadic existence?

被引：44

作者：

Buscaino, Alessia ^{[1
]}

Allshire, Robin ^{[1
]}

Pidoux, Alison ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Biol Sci, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 02期

基金：

英国惠康基金;

关键词：

FISSION YEAST SCM3; CENP-A NUCLEOSOMES; HISTONE H3 VARIANT; CHROMOSOME SEGREGATION; CHROMATIN; KINETOCHORE; HETEROCHROMATIN; SPECIFICATION; NEOCENTROMERE; COMPONENTS;

D O I：

10.1016/j.gde.2010.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Centromere assembly and propagation is governed by genetic and epigenetic mechanisms. A centromere-specific histone H3 variant, CENP-A is strongly favored as the epigenetic mark that specifies centromere identity. Despite the critical importance of centromere function, centromeric sequences are not conserved. This has prompted exploration of other genomic and chromatin features to gain an understanding of where CENP-A is deposited. In this review we highlight recent papers that advance our understanding of how the cell builds a centromere. We focus on what influences the choice of site for CENP-A deposition and therefore the site of centromere formation. We then briefly discuss how centromeres are propagated once the site of centromere assembly is chosen.

引用

页码：118 / 126

页数：9

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