Classical cadherin adhesion molecules: coordinating cell adhesion, signaling and the cytoskeleton

被引:115
作者
Goodwin, M [1 ]
Yap, AS [1 ]
机构
[1] Univ Queensland, Sch Biomed Sci, Inst Mol Biosci, Div Mol Cell Biol, St Lucia, Qld 4072, Australia
关键词
D O I
10.1007/s10735-004-1833-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Classical cadherin adhesion molecules are fundamental determinants of tissue organization in both health and disease. Recent advances in understanding the molecular and cellular basis of cadherin function have revealed that these adhesion molecules serve as molecular couplers, linking cell surface adhesion and recognition to both the actin cytoskeleton and cell signalling pathways. We will review some of these developments. to provide an overview of progress in this rapidly-developing area of cell and developmental biology.
引用
收藏
页码:839 / 844
页数:6
相关论文
共 51 条
  • [41] EXPERIMENTAL SPECIFICATION OF CELL SORTING, TISSUE SPREADING, AND SPECIFIC SPATIAL PATTERNING BY QUANTITATIVE DIFFERENCES IN CADHERIN EXPRESSION
    STEINBERG, MS
    TAKEICHI, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) : 206 - 209
  • [42] CADHERIN CELL-ADHESION RECEPTORS AS A MORPHOGENETIC REGULATOR
    TAKEICHI, M
    [J]. SCIENCE, 1991, 251 (5000) : 1451 - 1455
  • [43] MORPHOGENETIC ROLES OF CLASSIC CADHERINS
    TAKEICHI, M
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1995, 7 (05) : 619 - 627
  • [44] Cadherins in embryonic and neural morphogenesis
    Tepass, U
    Truong, K
    Godt, D
    Ikura, M
    Peifer, M
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (02) : 91 - 100
  • [45] Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium
    Vaezi, A
    Bauer, C
    Vasioukhin, V
    Fuchs, E
    [J]. DEVELOPMENTAL CELL, 2002, 3 (03) : 367 - 381
  • [46] N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane
    Wahl, JK
    Kim, YJ
    Cullen, JM
    Johnson, KR
    Wheelock, MJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) : 17269 - 17276
  • [47] Yagi T, 2000, GENE DEV, V14, P1169
  • [48] Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Yang, J
    Mani, SA
    Donaher, JL
    Ramaswamy, S
    Itzykson, RA
    Come, C
    Savagner, P
    Gitelman, I
    Richardson, A
    Weinberg, RA
    [J]. CELL, 2004, 117 (07) : 927 - 939
  • [49] The morphogenetic role of cadherin cell adhesion molecules in human cancer: A thematic review
    Yap, AS
    [J]. CANCER INVESTIGATION, 1998, 16 (04) : 252 - 261
  • [50] The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p129ctn
    Yap, AS
    Niessen, CM
    Gumbiner, BM
    [J]. JOURNAL OF CELL BIOLOGY, 1998, 141 (03) : 779 - 789