Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection

被引：178

作者：

Hocqueloux, Laurent ^{[1
]}

Prazuck, Thierry ^{[1
]}

Avettand-Fenoel, Veronique ^{[2
,3
]}

Lafeuillade, Alain ^{[4
]}

Cardon, Bernard ^{[5
]}

Viard, Jean-Paul ^{[3
,6
]}

Rouzioux, Christine ^{[2
,3
]}

机构：

[1] Ctr Hosp Reg, Serv Malad Infect & Trop, Orleans, France

[2] Hop Necker Enfants Malad, APHP, Virol Lab, Paris, France

[3] Univ Paris 05, EA 3620, Paris, France

[4] Hop Font Pre, Serv Malad Infect & Trop, Toulon, France

[5] Hop Tenon, Serv Malad Infect & Trop, F-75970 Paris, France

[6] Hop Necker Enfants Malad, Serv Malad Infect & Trop, Paris, France

来源：

AIDS | 2010年 / 24卷 / 10期

关键词：

VIRAL REPLICATION; DNA; BLOOD; CELLS; RESPONSES; IMPACT;

D O I：

10.1097/QAD.0b013e32833b61ba

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five out of 32 patients who received very early and prolonged antiretroviral therapy displayed an unusual, sustained immunovirological control after treatment discontinuation (mean duration: 77 months). These 'post-treatment controllers' did not have the genetic characteristics of spontaneous 'elite' controllers, although they shared very low and stable level of viral reservoir. Treatment may have dramatically decreased this reservoir and preserved potent HIV-specific immunologic responses, inducing a new balance between the virus and the host's immune system in these patients. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：1598 / 1601

页数：4

共 15 条

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