Probing single DNA molecule transport using fabricated nanopores

被引：325

作者：

Chen, P

Gu, JJ

Brandin, E

Kim, YR

Wang, Q

Branton, D ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

[3] SE Univ, Dept Radio Engn, Nanjing 210096, Peoples R China

来源：

NANO LETTERS | 2004年 / 4卷 / 11期

关键词：

D O I：

10.1021/nl048654j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanopores can serve as high throughput, single-molecule sensing devices that provide insight into the distribution of static and dynamic molecular activities, properties, or interactions. We have studied double stranded DNA electrophoretic transport dynamics through fabricated nanopores in silicon nitride. A fabricated pore enables us to interrogate a broader range of molecules with a wider range of conditions than can be investigated in a self-assembled protein pore in a lipid membrane.

引用

页码：2293 / 2298

页数：6

共 35 条

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