Characteristics of prolactin-releasing response to salsolinol in vivo in cattle

被引：11

作者：

Hashizume, T. ^{[1
]}

Sawada, T. ^{[1
]}

Yaegashi, T. ^{[1
]}

Saito, H. ^{[1
]}

Ahmed, A. Ezzat ^{[1
]}

Goto, Y. ^{[1
]}

Nakajima, Y. ^{[1
]}

Jin, J. ^{[1
]}

Kasuya, E. ^{[2
]}

Nagy, G. M. ^{[3
,4
]}

机构：

[1] Iwate Univ, Fac Agr, Morioka, Iwate 0208550, Japan

[2] Natl Inst Agrobiol Sci, Lab Anim Neurophysiol, Tsukuba, Ibaraki, Japan

[3] Hungarian Acad Sci, Dept Human Morphol, Neuromorphol & Neuroedocrine Res Lab, Budapest, Hungary

[4] Semmelweis Univ, Budapest, Hungary

来源：

DOMESTIC ANIMAL ENDOCRINOLOGY | 2010年 / 39卷 / 01期

基金：

日本学术振兴会;

关键词：

Salsolinol; Prolactin; Cattle; Dopamine; SUCKLING-INDUCED PROLACTIN; PHYSIOLOGICAL-ROLE; PITUITARY-GLAND; SECRETION; RUMINANTS; DOPAMINE; BRAIN; RAT;

D O I：

10.1016/j.domaniend.2010.01.002

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The aims of the present study were to clarify the effect of salsolinol (SAL), a dopamine (DA)-derived endogenous compound, on the secretion of prolactin (PRL) in cattle. The experiments were performed from April to June using calves and cows. A single intravenous (i.v.) injection of SAL (5 mg/kg body weight [BW]) or sulpiride (a DA receptor antagonist, 0.1 mg/kg BW) significantly stimulated the release of PRL in male and female calves (P <0.05), though the response to SAL was smaller than that to sulpiride. The secretory pattern of PRL in response to SAL or sulpiride in female calves resembled that in male calves. A single i.v. injection of SAL or sulpiride significantly stimulated the release of PRL in cows (P <0.05). There was no significant difference in the PRL-releasing response between the SAL- and sulpiride-injected groups in cows. A single intracerebroventricular injection of SAL (10 mg/head) also significantly stimulated the release of PRL in castrated calves (P <0.05). These results show that SAL is involved in the regulatory process for the secretion of PRL, not only in male and female calves, but also in cows. The results also suggest that the potency of the PRL-releasing response to SAL differs with the physiological status of cattle. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：21 / 25

页数：5

共 18 条

[1] Neurochemical changes induced by acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline and salsolinol in dopaminergic structures of rat brain [J].