Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes

被引：63

作者：

Ghisalberti, D ^{[1
]}

Masi, M ^{[1
]}

Pagès, JM ^{[1
]}

Chevalier, J ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med, IFR48, EA2197, F-13385 Marseille 05, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 328卷 / 04期

关键词：

efflux pump; Enterobacter aerogenes; chloramphenicol; efflux pump inhibitor; multidrug resistance;

D O I：

10.1016/j.bbrc.2005.01.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chloramphenicol has been reported to act as an inducer of the multidrug resistance in Escherichia coli. A resistant variant able to grow on plates containing 64 mug/ml chloramphenicol was obtained from the Enterobacter aerogenes ATCC 13048-type strain. Chloramphenicol resistance was due to an active efflux of this antibiotic and it was associated with resistance to fluoroquinolones and tetracycline, but not to aminoglycoside or beta-lactam antibiotics. MDR in the chloramphenicol-resistant variant is linked to the overexpression of the major AcrAB-TolC efflux system. This overexpression seems unrelated to the global Mar and the local AcrR regulatory pathways. (C) 2005 Published by Elsevier Inc.

引用

页码：1113 / 1118

页数：6

共 31 条

[21] Porin alteration and active efflux:: two in vivo drug resistance strategies used by Enterobacter aerogenes [J].

Mallea, M ;

Chevalier, J ;

Bornet, C ;

Eyraud, A ;

Davin-Regli, A ;

Bollet, C ;

Pagès, JM .

MICROBIOLOGY-UK, 1998, 144 :3003-3009

[22] Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains [J].

Malléa, M ;

Chevalier, J ;

Eyraud, A ;

Pagès, JM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 293 (05) :1370-1373

[23] Identification of mar mutants among quinolone-resistant clinical isolates of Escherichia coli [J].

Maneewannakul, K ;

Levy, SB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (07) :1695-1698

[24] Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum β-lactamase production [J].

Martínez-Martínez, L ;

Pascual, A ;

Conejo, MD ;

García, I ;

Joyanes, P ;

Doménech-Sánchez, A ;

Benedí, VJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (12) :3926-3932

[25] ACTIVE EFFLUX OF CHLORAMPHENICOL IN SUSCEPTIBLE ESCHERICHIA-COLI STRAINS AND IN MULTIPLE-ANTIBIOTIC-RESISTANT (MAR) MUTANTS [J].

MCMURRY, LM ;

GEORGE, AM ;

LEVY, SB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (03) :542-546

[26] Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli [J].

Oethinger, M ;

Podglajen, I ;

Kern, WV ;

Levy, SB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (08) :2089-2094

[27] The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes [J].

Pradel, E ;

Pagès, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (08) :2640-2643

[28] Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium [J].

Prouty, AM ;

Brodsky, IE ;

Falkow, S ;

Gunn, JS .

MICROBIOLOGY-SGM, 2004, 150 :775-783

[29] Molecular basis of bacterial resistance to chloramphenicol and florfenicol [J].

Schwarz, S ;

Kehrenberg, C ;

Doublet, B ;

Cloeckaert, A .

FEMS MICROBIOLOGY REVIEWS, 2004, 28 (05) :519-542

[30] THE RELIABILITY OF METHODS FOR DETECTING CHLORAMPHENICOL RESISTANCE IN HEMOPHILUS-INFLUENZAE [J].

WALKER, CW ;

BROWN, DFJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (06) :905-910

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