Chronic myeloid leukaemia as a model of disease evolution in human cancer

被引：454

作者：

Melo, Junia V. ^{[1
]}

Barnes, David J. ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll London, Dept Haematol, London W12 0NN, England

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 06期

关键词：

D O I：

10.1038/nrc2147

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that evolve through a multi-step process. CML is also one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease. If not cured at this stage, CML invariably progresses and transforms into an acute-type leukaemia undergoing a 'blast crisis'. The causes of this transformation are still poorly understood. What mechanisms underlie this progression, and are they shared by other common cancers?

引用

页码：441 / 453

页数：13

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