Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family

被引：20

作者：

Ichigotani, Y

Matsuda, S

Machida, K

Oshima, K

Iwamoto, T

Yamaki, K

Hayakawa, T

Hamaguchi, M

机构：

[1] Nagoya Univ, Sch Med, Dept Mol Pathogenesis, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Sch Med, Dept Internal Med 2, Nagoya, Aichi 4668550, Japan

[3] Nagoya Univ, Sch Med, Dept Ophthalmol, Nagoya, Aichi 4668550, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2000年 / 45卷 / 06期

关键词：

SIRP; SHPS-1; glycoprotein; chromosome; 20p13; RH mapping;

D O I：

10.1007/s100380070013

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1735 base pairs and has a predicted open reading frame (ORF) encoding 354 amino acids. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain, which is highly homologous to signal-regulatory protein (SIRP)-beta, suggest ins that it seems to be a new member of the SIRP family. Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906.

引用

页码：378 / 382

页数：5

共 20 条

[1] Cutting edge:: Signal-regulatory protein β1 is a DAP12-associated activating receptor expressed in myeloid cells [J].