Heparin-Induced Thrombocytopenia

被引：74

作者：

Arepally, Gowthami M. ^{[1
]}

Ortel, Thomas L. ^{[2
,3
]}

机构：

[1] Duke Univ, Med Ctr, Div Hematol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Ctr Thrombosis & Hemostasis, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Pathol, Ctr Thrombosis & Hemostasis, Durham, NC 27710 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2010年 / 61卷

基金：

美国国家卫生研究院;

关键词：

platelet factor 4; heparin; thrombosis; immunoassays; direct thrombin inhibitors; immune thrombocytopenia; immune-mediated thrombosis; MOLECULAR-WEIGHT HEPARIN; PLATELET-AGGREGATION TEST; OPTICAL-DENSITY VALUES; CARDIOPULMONARY BYPASS; THROMBOEMBOLIC COMPLICATIONS; UNFRACTIONATED HEPARIN; RISK-FACTORS; ANTIBODIES; THROMBOSIS; DIAGNOSIS;

D O I：

10.1146/annurev.med.042808.171814

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Heparin-induced thrombocytopenia (HIT) is an immune-mediated hypercoagulable disorder caused by antibodies to platelet factor 4 (PF4) and heparin. HIT develops in temporal association with heparin therapy and manifests either as an unexplained thrombocytopenia or thrombocytopenia complicated by thrombosis. The propensity for thrombosis distinguishes HIT from other common drug-induced thrombocytopenias. Diagnosing HIT in hospitalized patients is often challenging because of the frequency of heparin use, occurrence of thrombocytopenia from other causes, and development of asymptomatic PF4/heparin antibodies in patients treated with heparin. This review summarizes our current understanding of the pathogenesis, clinical features, diagnostic criteria, and management approaches in HIT

引用

页码：77 / 90

页数：14

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