DegrAAAded into silence

被引：7

作者：

Bayne, Elizabeth H. ^{[1
]}

White, Sharon A. ^{[1
]}

Allshire, Robin C. ^{[1
]}

机构：

[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

CELL | 2007年 / 129卷 / 04期

关键词：

D O I：

10.1016/j.cell.2007.05.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In fission yeast, RNA interference (RNAi)-dependent heterochromatin formation silences transgenes inserted at centromeres. In this issue, Buhler et al. (2007) demonstrate that the RNAi machinery directly targets transgene transcripts. Furthermore, they link transgene silencing to a protein complex resembling the TRAMP complex of budding yeast, which promotes transcript degradation via the exosome. Thus, RNAi-independent transcript degradation may also contribute to heterochromatin gene silencing.

引用

页码：651 / 653

页数：3

共 10 条

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