Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers

被引：60

作者：

Blizzard, TA ^{[1
]}

DiNinno, F ^{[1
]}

Morgan, JD ^{[1
]}

Chen, HY ^{[1
]}

Wu, JY ^{[1
]}

Kim, S ^{[1
]}

Chan, W ^{[1
]}

Birzin, ET ^{[1
]}

Yang, YT ^{[1
]}

Pai, LY ^{[1
]}

Fitzgerald, PMD ^{[1
]}

Sharma, N ^{[1
]}

Li, Y ^{[1
]}

Zhang, ZP ^{[1
]}

Hayes, EC ^{[1
]}

DaSilva, CA ^{[1
]}

Tang, W ^{[1
]}

Rohrer, SP ^{[1
]}

Schaeffer, JM ^{[1
]}

Hammond, ML ^{[1
]}

机构：

[1] Merck Res Labs, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 01期

关键词：

SERMs; SERAMs; estrogen;

D O I：

10.1016/j.bmcl.2004.10.036

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of dihydrobenzoxathlin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：107 / 113

页数：7

共 19 条

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