Titanium dioxide nanotubes enhance bone bonding in vivo

被引：302

作者：

Bjursten, Lars M. ^{[1
,2
]}

Rasmusson, Lars ^{[3
]}

Oh, Seunghan ^{[4
,5
]}

Smith, Garrett C. ^{[1
,2
]}

Brammer, Karla S. ^{[4
]}

Jin, Sungho ^{[4
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Lund Univ, Malmo, Sweden

[3] Univ Gothenburg, Dept Oral & Maxillofacial Surg, Sahlgrenska Acad, Gothenburg, Sweden

[4] Univ Calif San Diego, Mat Sci & Engn Program, Dept Mech & Aerosp Engn, La Jolla, CA 92093 USA

[5] Wonkwang Univ, Coll Dent, Dept Dent Biomat, Iksan, South Korea

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2010年 / 92A卷 / 03期

关键词：

titanium dioxide nanotube; bone implant; osseointegration; mechanical strength; histology; SURFACE; IMPLANTS; MORPHOLOGY; COATINGS; ADHESION; GROWTH;

D O I：

10.1002/jbm.a.32463

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Implant topography is critical to the clinical Success of bone-anchored implants, yet little is known how nano-modified implant topography affects osseointegration. We investigate the in vivo bone bonding of two titanium implant surface: titanium dioxide (TiO(2)) nanotubes and TiO(2) gritblasted surfaces. In previous in vitro studies, the topography of the TiO(2) nanotubes improved osteoblast proliferation and adhesion compared with gritblasted titanium Surfaces. After four weeks of implantation in rabbit tibias, pull-out testing indicated that TiO(2) nanotubes significantly improved bone bonding strength by as much as nine-fold compared with TiO(2) gritblasted surfaces. Histological analysis confirmed greater bone-implant contact area, new bone formation, and calcium and phosphorus levels on the nanotube surfaces. It is anticipated that further studies will contribute to a better understanding of the effect of implant nanotopography on in vivo bone formation and bonding strength. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 1218-1224, 2016

引用

页码：1218 / 1224

页数：7

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