The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study: To what extent should the results be generalizable?

被引：28

作者：

Gerschutz, GP ^{[1
]}

Bhatt, DL ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA

来源：

AMERICAN HEART JOURNAL | 2003年 / 145卷 / 04期

关键词：

D O I：

10.1067/mhj.2003.180

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study investigated the use of clopidogrel in the treatment of acute coronary syndromes. Clopidogrel treatment led to an impressive 20% relative risk reduction in the composite outcome measure of vascular death, myocardial infarction, and stroke. Increased bleeding and greater requirements for blood transfusions were seen with clopidogrel. The addition-of clopidogrel to aspirin represents a major advance in the treatment of acute coronary syndromes.

引用

页码：595 / 601

页数：7

共 35 条

[1] COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS [J].

ALTMAN, R ;

CARRERAS, L ;

DIAZ, R ;

FIGUEROA, E ;

PAOLASSO, E ;

PARODI, JC ;

CADE, JF ;

DONNAN, G ;

EADIE, MJ ;

GAVAGHAN, TP ;

OSULLIVAN, EF ;

PARKIN, D ;

RENNY, JTG ;

SILAGY, C ;

VINAZZER, H ;

ZEKERT, F ;

ADRIAENSEN, H ;

BERTRANDHARDY, JM ;

BRAN, M ;

DAVID, JL ;

DRICOT, J ;

LAVENNEPARDONGE, E ;

LIMET, R ;

LOWENTHAL, A ;

MORIAU, M ;

SCHAPIRA, S ;

SMETS, P ;

SYMOENS, J ;

VERHAEGHE, R ;

VERSTRAETE, M ;

ATALLAH, A ;

BARNETT, H ;

BATISTA, R ;

BLAKELY, J ;

CAIRNS, JA ;

COTE, R ;

CROUCH, J ;

EVANS, G ;

FINDLAY, JM ;

GENT, M ;

LANGLOIS, Y ;

LECLERC, J ;

NORRIS, J ;

PINEO, GF ;

POWERS, PJ ;

ROBERTS, R ;

SCHWARTZ, L ;

SICURELLA, J ;

TAYLOR, W ;

THEROUX, P .

BMJ-BRITISH MEDICAL JOURNAL, 1994, 308 (6921) :81-100

[2]

American Heart Association (AHA), HEART STROK STAT UPD

[3]

[Anonymous], 1988, BRIT MED J, V296, P320

[4] Clopidogrel versus ticlopidine after intracoronary stent placement [J].

Berger, PB ;

Bell, MR ;

Rihal, CS ;

Ting, H ;

Barsness, G ;

Garratt, K ;

Bellot, V ;

Mathew, V ;

Melby, S ;

Hammes, L ;

Grill, D ;

Holmes, DR .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 34 (07) :1891-1894

[5]

Berger PB, 2001, ACUTE CORONARY SYNDROMES, SECOND EDITION, P453

[6] Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting - The Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS) [J].

Bertrand, ME ;

Rupprecht, HJ ;

Urban, P ;

Gershlick, AH .

CIRCULATION, 2000, 102 (06) :624-629

[7] Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting - The full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study [J].

Bertrand, ME ;

Legrand, V ;

Boland, J ;

Fleck, E ;

Bonnier, J ;

Emmanuelson, H ;

Vrolix, M ;

Missault, L ;

Chierchia, S ;

Casaccia, M ;

Niccoli, L ;

Oto, A ;

White, C ;

Webb-Peploe, M ;

Van Belle, E ;

McFadden, EP .

CIRCULATION, 1998, 98 (16) :1597-1603

[8] Amplified benefit of Clopidogrel versus aspirin in patients with diabetes mellitus [J].

Bhatt, DL ;

Marso, SP ;

Hirsch, AT ;

Ringleb, PA ;

Hacke, W ;

Topol, EJ .

AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (06) :625-+

[9] Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting [J].

Bhatt, DL ;

Bertrand, ME ;

Berger, PB ;

L'Allier, PL ;

Moussa, I ;

Moses, JW ;

Dangas, G ;

Taniuchi, M ;

Lasala, JM ;

Holmes, DR ;

Ellis, SG ;

Topol, EJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (01) :9-14

[10]

Bhatt DL, 2001, CIRCULATION, V103, P363

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