The Evolution of Human Genetic and Phenotypic Variation in Africa

被引：119

作者：

Campbell, Michael C. ^{[1
]}

Tishkoff, Sarah A. ^{[1
,2
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Arts & Sci, Dept Biol, Philadelphia, PA 19104 USA

来源：

CURRENT BIOLOGY | 2010年 / 20卷 / 04期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

LACTASE PERSISTENCE/NON-PERSISTENCE; PYGMY HUNTER-GATHERERS; Y-CHROMOSOME; COPY-NUMBER; LINKAGE DISEQUILIBRIUM; POPULATION-STRUCTURE; X-CHROMOSOME; HAPLOTYPE DIVERSITY; NATURAL-SELECTION; WORLDWIDE SURVEY;

D O I：

10.1016/j.cub.2009.11.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Africa is the birthplace of modern humans, and is the source of the geographic expansion of ancestral populations into other regions of the world. Indigenous Africans are characterized by high levels of genetic diversity within and between populations. The pattern of genetic variation in these populations has been shaped by demographic events occurring over the last 200,000 years. The dramatic variation in climate, diet, and exposure to infectious disease across the continent has also resulted in novel genetic and phenotypic adaptations in extant Africans. This review summarizes some recent advances in our understanding of the demographic history and selective pressures that have influenced levels and patterns of diversity in African populations.

引用

页码：R166 / R173

页数：8

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