A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides

被引：101

作者：

Chen, Jin ^{[1
]}

Wang, Ping ^{[1
]}

Zhu, Jianglong ^{[1
]}

Wan, Qian ^{[1
]}

Danishefsky, Samuel J. ^{[1
,2
]}

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10065 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

TETRAHEDRON | 2010年 / 66卷 / 13期

基金：

美国国家卫生研究院;

关键词：

NATIVE CHEMICAL LIGATION; FOLLICLE-STIMULATING-HORMONE; HUMAN PITUITARY-GLANDS; AMINO-ACID SEQUENCE; PROTEIN GLYCOSYLATION; TRIALKYL PHOSPHITES; THIYL RADICALS; GLYCOPROTEIN; DESULFURIZATION; PEPTIDES;

D O I：

10.1016/j.tet.2010.01.067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method by which to accomplish formal threonine ligation has been developed. The method accomplishes ligations of two peptide domains. We have also demonstrated the ability to successfully ligate two independent glycopeptide domains. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2277 / 2283

页数：7

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