Kindling suppresses primed-burst-induced long-term potentiation in hippocampal CAI

被引：29

作者：

Leung, LS

Wu, CP

机构：

[1] Univ Western Ontario, Dept Clin Neurol Sci, London Hlth Sci Ctr, London, ON N6A 5A5, Canada

[2] Univ Western Ontario, Dept Physiol, London Hlth Sci Ctr, London, ON N6A 5A5, Canada

来源：

NEUROREPORT | 2003年 / 14卷 / 02期

关键词：

GABA(B) receptors; hippocampus; kindling; long-term potentiation; temporal lobe epilepsy; theta-frequency primed burst;

D O I：

10.1097/00001756-200302100-00010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a previous study, we showed that partial hippocampal kindling in rats, a model of temporal lobe epilepsy, reduced the efficacy of presynaptic GABA(B) receptors in the CAI area of hippocampal slices in vitro. In this study, we show that long-term potentiation (LTP) induced by theta-frequency primed bursts in vitro was suppressed in kindled as compared to control rats, but not in the presence of the GABA(B) receptor antagonists CGP35348 orCGP55845A. This is original evidence that LTP is suppressed by pathophysiological downregulation of GABA(B) autoreceptors. Control of postsynaptic inhibition by presynaptic GABA(B) receptors may provide a compensatory mechanism for controlling paroxysmal activity, with a side effect of blocking synaptic plasticity.

引用

页码：211 / 214

页数：4

共 25 条

[1] A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].