Organocatalytic asymmetric hydrophosphination of α,β-Unsaturated aldehydes

被引：149

作者：

Carlone, Armando ^{[1
]}

Bartoli, Giuseppe ^{[1
]}

Bosco, Marcella ^{[1
]}

Sambri, Letizia ^{[1
]}

Melchiorre, Paolo ^{[1
]}

机构：

[1] Univ Bologna, Dept Organ Chem A Mangini Alma Mater Studiorum, I-40136 Bologna, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

aldehydes; asymmetric synthesis; conjugate addition; organocatalysis; phosphanes;

D O I：

10.1002/anie.200700754

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Getting round the (periodic) table: A highly chemo- and enantioselective conjugate addition of diphenylphosphine to α,β-unsaturated aldehydes in the presence of a chiral secondary amine C provides a direct route to chiral β-phosphino aldehyde intermediates (see scheme, TMS = trimethylsilyl). The synthetic utility of the strategy was exemplified in a rapid one-pot (two-step) synthesis of highly enantioenriched 3-amino-phosphines. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4504 / 4506

页数：3

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