Growth factor-induced therapeutic angiogenesis in the heart: protein therapy

被引：69

作者：

Annex, BH

Simons, M ^{[1
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Cardiol Sect, Dept Med, Dartmouth Med Sch, Lebanon, NH 03756 USA

[2] Dartmouth Hitchcock Med Ctr, Dept Pharmacol & Toxicol, Dartmouth Med Sch, Lebanon, NH 03756 USA

[3] Duke Univ, Med Ctr, Durham, NC USA

[4] Durham Vet Adm, Dept Med, Div Cardiol, Durham, NC USA

来源：

CARDIOVASCULAR RESEARCH | 2005年 / 65卷 / 03期

关键词：

angiogenesis; arteriogenesis; growth factors; clinical trial; protein therapy;

D O I：

10.1016/j.cardiores.2004.09.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Therapeutic angiogenesis, stimulated growth of new vasculature to compensate for tissue ischemia, remains an unfulfilled promise. After nearly a decade of trials, the development of drugs capable of stimulating revascularization of underperfused tissues remains an exciting but unrealized goal in cardiovascular therapeutics. This review will summarize experiences in therapeutic angiogenesis studies employing protein therapies and will draw conclusions based on our current understanding of biological processes of new vessel growth. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：649 / 655

页数：7

共 59 条

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*AM HEART ASS, 2003, HEART DIS STROK STAT

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