Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

被引：243

作者：

Steiner, H ^{[1
]}

Kostka, M

Romig, H

Basset, G

Pesold, B

Hardy, J

Capell, A

Meyn, L

Grim, ML

Baumeister, R

Fechteler, K

Haass, C

机构：

[1] Univ Munich, Adolf Butenandt Inst, Dept Biochem, Lab Alzheimers Dis Res, D-80336 Munich, Germany

[2] Boehringer Ingelheim Pharma KG, CNS Res, D-55216 Ingelheim, Germany

[3] Mayo Clin, Jacksonville, FL 32224 USA

[4] Univ Munich, Gene Ctr, D-81377 Munich, Germany

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 11期

关键词：

D O I：

10.1038/35041097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Endoproteolysis of beta -amyloid precursor protein (beta APP) and Notch requires conserved aspartate residues in presenilins 1 and 2 (PS1 and PS2). Although PS1 and PS2 have therefore been proposed to be aspartyl proteases, no homology to other aspartyl proteases has been found. Here we identify homology between the presenilin active site and polytopic aspartyl proteases of bacterial origin, thus supporting the hypothesis that presenilins are novel aspartyl proteases.

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页码：848 / 851

页数：4

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