mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis

被引：103

作者：

Laplante, Mathieu ^{[1
,2
]}

Sabatini, David M. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02142 USA

[3] MIT, Koch Ctr Integrat Canc Res, Cambridge, MA 02142 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 08期

关键词：

INSULIN-RESISTANCE; AMINO-ACID; MAMMALIAN TARGET; TRANSCRIPTION; CONTRIBUTES; OBESITY; LIVER;

D O I：

10.1073/pnas.1000323107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：3281 / 3282

页数：2

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