ASTROCYTES: ORCHESTRATING SYNAPTIC PLASTICITY?

被引：173

作者：

De Pitta, M. ^{[1
,2
]}

Brunel, N. ^{[1
,3
]}

Volterra, A. ^{[4
]}

机构：

[1] Univ Chicago, Dept Neurobiol, 947 East 58th St,MC 0928,Room AB320, Chicago, IL 60637 USA

[2] INRIA Rhone Alpes, EPI BEAGLE, Villeurbanne, France

[3] Univ Chicago, Dept Stat, Chicago, IL 60637 USA

[4] Univ Lausanne, Dept Neurosci Fondamentales, Rue Bugnon 9, CH-1005 Lausanne, Switzerland

来源：

NEUROSCIENCE | 2016年 / 323卷

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

synaptic plasticity; astrocyte; gliotransmission; LONG-TERM POTENTIATION; TIMING-DEPENDENT PLASTICITY; D-SERINE; AMPA RECEPTOR; NMDA RECEPTORS; TRANSMITTER RELEASE; CALCIUM WAVES; TNF-ALPHA; IN-SITU; HETEROSYNAPTIC DEPRESSION;

D O I：

10.1016/j.neuroscience.2015.04.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that remains debated is how the plasticity mechanisms, that encompass a broad spectrum of temporal and spatial scales, come to play together in a concerted fashion. Here we review and discuss evidence that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes. This article is part of a Special Issue entitled: Astrocyte-Neuron Interact. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：43 / 61

页数：19

共 237 条

[1]

Synaptic plasticity: taming the beast [J].