Nucleation of one polymorph by another

被引：167

作者：

Yu, L ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 21期

关键词：

D O I：

10.1021/ja0351544

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nucleation of one polymorph by another has been observed directly in the melt crystallization of d-mannitol and d-sorbitol. The new polymorph nucleated on an existing one and grew to dominate the end product. This effect is relevant to controlling polymorphism in the manufacture of specialty chemicals and to developing theories of polymorphic nucleation and concomitant polymorphs, for which current efforts emphasize homogeneous nucleation of alternative polymorphs. Copyright © 2003 American Chemical Society.

引用

页码：6380 / 6381

页数：2

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