A review of the herbal phosphodiesterase inhibitors; Future perspective of new drugs

被引：111

作者：

Rahimi, Roja ^{[2
,3
]}

Ghiasi, Sima ^{[1
,3
]}

Azimi, Hanieh ^{[1
,3
]}

Fakhari, Sima ^{[1
,3
]}

Abdollahi, Mohammad ^{[1
,3
]}

机构：

[1] Tehran Univ Med Sci, Fac Pharm, Tehran 1417614411, Iran

[2] Tehran Univ Med Sci, Fac Tradit Med, Tehran 1417614411, Iran

[3] Tehran Univ Med Sci, Pharmaceut Sci Res Ctr, Tehran 1417614411, Iran

来源：

CYTOKINE | 2010年 / 49卷 / 02期

关键词：

Phosphodiesterase inhibitors; Natural; cGMP; cAMP; CYCLIC-AMP PHOSPHODIESTERASE; ADENOSINE 3,5-CYCLIC-MONOPHOSPHATE PHOSPHODIESTERASE; INDUCED OXIDATIVE STRESS; NUCLEOTIDE PHOSPHODIESTERASES; IN-VITRO; CORPUS CAVERNOSUM; MEDICINAL-PLANTS; SMOOTH-MUSCLE; CAMP-PHOSPHODIESTERASE; SELECTIVE-INHIBITION;

D O I：

10.1016/j.cyto.2009.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphodiesterase inhibitors (PDEIs) are a class of drugs that are widely used because of their various pharmacological properties including cardiotonic, vasodilator, smooth muscle relaxant, antidepressant, antithrombotic, bronchodilator, and inflammatory and enhancer of cognitive function. In the recent years, interest in drugs of plant origin has been progressively increased. Some pharmacologically active substances that come from plants demonstrate PDEI activity. They mainly belong to alkaloids, flavonoids, and saponins. In this review, studies on herbal PDEI were reviewed and their possible therapeutic applications were discussed. Screening plants for PDE inhibitory activity may help to develop standardized phytotherapeutic products or find new sources for new lead structures with PDEI pharmacological activity. The studies discussed in this paper are mainly in vitro and for more reasonable and conclusive results, it is required to conduct in vivo and finally human and clinical tests. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：123 / 129

页数：7

共 115 条

[1] Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat submandibular gland and saliva [J].