An assessment of different filter systems for extracorporeal elimination of bivalirudin:: An in vitro study

被引：46

作者：

Koster, A

Chew, D

Gründel, M

Hausmann, H

Grauhan, O

Kuppe, H

Spiess, BD

机构：

[1] Deutsch Herzzentrum Berlin, Dept Anesthesia, D-13353 Berlin, Germany

[2] Deutsch Herzzentrum Berlin, Dept Thorac & Cardiovasc Surg, D-13353 Berlin, Germany

[3] Flinders Med Ctr, Dept Cardiol, Adelaide, SA, Australia

[4] Virginia Commonwealth Univ, Dept Cardiothorac Anesthesia, Richmond, VA USA

来源：

ANESTHESIA AND ANALGESIA | 2003年 / 96卷 / 05期

关键词：

D O I：

10.1213/01.ANE.0000057605.61063.55

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Bivalirudin is a new, direct thrombin inhibitor. We investigated the extracorporeal elimination rate of different hemofilters and one plasmapheresis filter for bivalirudin. Our data show that bivalirudin can be effectively eliminated via hemofiltration and plasmapheresis, although there were significant differences in the elimination rates among the filter systems investigated.

引用

页码：1316 / 1319

页数：4

共 8 条

[1]

Bates S M, 2000, J Invasive Cardiol, V12 Suppl F, p27F

[2]

Chew DP, 2002, HAMOSTASEOLOGIE, V22, P142

[3] Recombinant hirudin as an alternative for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II: A 1-year experience in 57 patients [J].