Clickable peptide nucleic acids (cPNA) with tunable affinity

被引：20

作者：

Chouikhi, Dalila ^{[1
]}

Barluenga, Sofia ^{[1
]}

Winssinger, Nicolas ^{[1
]}

机构：

[1] Univ Strasbourg, ISIS, UMR 7006, CNRS, F-67000 Strasbourg, France

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 30期

基金：

欧洲研究理事会;

关键词：

AZIDE-ALKYNE CYCLOADDITION; TERMINAL ALKYNES; PNA SYNTHESIS; SOLID-PHASE; DNA; LIGATION; OLIGONUCLEOTIDES; AMPLIFICATION; MICROARRAYS; CHEMISTRY;

D O I：

10.1039/c0cc01081b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a "click" cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments.

引用

页码：5476 / 5478

页数：3

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