Synthesis of αβ-unsaturated trifluoromethyl ketones from 4-dimethylamino-1,1,1-trifluorobut-3-ene-2-one by addition of Grignard reagents

被引：45

作者：

Andrew, RJ ^{[1
]}

Mellor, JM ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 37期

关键词：

addition; Grignard reagents; organolithium; trifluoromethyl-ketones;

D O I：

10.1016/S0040-4020(00)00597-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enaminones are available by reaction of 4-ethoxy-1,1,1-trifluorobut-3-ene-2-one with amines such as dimethylamine and they react with Grignard reagents to give alpha beta-unsaturated trifluoromethyl ketones in good yield by 1,4-addition followed by elimination. The generality of this procedure is contrasted with reactions based either on the use of organolithium nucleophiles, or the use of 4-alkoxy-alpha beta-unsaturated trifluoromethyl ketones as electrophilic partners. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7261 / 7266

页数：6

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