A novel one-pot reductive amination of aldehydes and ketones with lithium perchlorate and zirconium borohydride-piperazine complexes

被引：32

作者：

Heydari, Akbar

Khaksar, Samad

Esfandyari, Maryam

Tajbakhsh, Mahmoud

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[2] Mazandaran Univ, Dept Chem, Babol Sar, Iran

来源：

TETRAHEDRON | 2007年 / 63卷 / 16期

关键词：

direct reductive amination; LiClO4; zirconium borohydride-piperazine complex; imine; iminium ion; oxime; hydrazone;

D O I：

10.1016/j.tet.2007.02.026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot reductive mono-alkylation method of amines (primary and secondary), 1,2-phenylenediamine, O-trimethylsilyl-hydroxylamine, and N,N-dimethylhydrazine was developed using LiClO4 (5 mol %) as a source for in situ generation of imine, iminium ion, oxime, and hydrazone, and zirconium borohydride-piperazine complex as reducing agent. This condition is especially useful for situations in which it is not practical to use the amine in excess (as is typically the case under acid-catalyzed conditions) or for acid-sensitive compounds. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3363 / 3366

页数：4

共 35 条

[1] Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J].