AMP-activated protein kinase counteracted the inhibitory effect of glucose on the phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes

被引：20

作者：

Hubert, A

Husson, A

Chédeville, A

Lavoinne, A

机构：

[1] UFR Med Pharm Rouen, Grp Apparell Digest Environm Nutr, F-76183 Rouen, France

[2] UFR Med Pharm Rouen, Inst Federatif Rech Multidisciplinaires Peptides, F-76183 Rouen, France

来源：

FEBS LETTERS | 2000年 / 481卷 / 03期

关键词：

AMP kinase; phosphoenolpyruvate carboxykinase; glucose; AICAR; hepatocyte;

D O I：

10.1016/S0014-5793(00)02006-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of AMP-activated protein kinase (AMPK) in the regulation of the phosphoenolpyruvate carboxykinase (PEPCK) gene expression was studied in isolated rat hepatocytes, Activation of AMPK by AICAR counteracted the inhibitory effect of glucose on the PEPCK gene expression, both at the mRNA and the transcriptional levels. It is proposed that a target for AMPK is involved in the inhibitory effect of glucose on PEPCK gene transcription. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：209 / 212

页数：4

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