Synthesis of epibatidine homologues: Homoepibatidine and bis-homoepibatidine

被引：50

作者：

Malpass, JR

Hemmings, DA

Wallis, AL

机构：

[1] Department of Chemistry, University of Leicester

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 22期

关键词：

D O I：

10.1016/0040-4039(96)00687-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic approaches are described leading to homoepibatidine and bis-homoepibatidine which are based, respectively, on the tropane (8-azabicyclo[3.2.1]octane) and homotropane (9-azabicyclo[4.2.1]nonane) ring systems. Epoxy- tropanes and -homotropanes (which are readily available from simple cyclic dienes) are convenient precursors for the azabicyclic alkenes needed for the key reductive coupling with pyridine derivatives. Copyright (C) 1996 Elsevier Science Ltd

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页码：3911 / 3914

页数：4

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