Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library

被引：19

作者：

Antonow, Dyeison

Cooper, Nectaroula

Howard, Philip W.

Thurston, David E.

机构：

[1] Spirogen Ltd, London NW1 0NH, England

[2] Univ London, Sch Pharm, Canc Res UK Gene Targeted Drug Design Res Grp, London WC1N 1AX, England

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2007年 / 9卷 / 03期

关键词：

D O I：

10.1021/cc0601332

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A 66-member C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library has been successfully synthesized in parallel via Suzuki coupling using PS-PPh3Pd (catalyst) and PS-DEAM (scavenger) under microwave radiation. Library members were obtained in sufficient yield (up to 91%) and purity (85-98% crude) for biological evaluation.

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收藏

页码：437 / 445

页数：9

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