The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity

被引：34

作者：

Chooniedass-Kothari, Shilpa ^{[1
,3
]}

Vincett, Daniel ^{[2
,3
]}

Yan, Yi ^{[1
,3
]}

Cooper, Charlton ^{[1
,3
]}

Hamedani, Mohammad K. ^{[1
,3
]}

Myal, Yvonne ^{[2
]}

Leygue, Etienne ^{[1
,3
]}

机构：

[1] Univ Manitoba, Dept Biochem & Med Genet, Winnipeg, MB R3E 0W3, Canada

[2] Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 0W3, Canada

[3] Univ Manitoba, MICB, Winnipeg, MB R3E 0W3, Canada

来源：

FEBS LETTERS | 2010年 / 584卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Steroid receptor RNA activator; Steroid receptor RNA activator protein; Transcriptional activator; Estrogen receptor alpha; PROSTATE-CANCER CELLS; COACTIVATOR PROTEIN; SRA; EXPRESSION; COREPRESSORS; ISOFORMS; P68/P72; BINDING;

D O I：

10.1016/j.febslet.2010.02.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The steroid receptor RNA activator gene (SRA1) encodes for a functional RNA (SRA) as well as a protein (SRAP). While several groups reported on SRA-RNA mechanism of action, SRAP exact function remains to be elucidated, mainly due to a lack of studies investigating the function of the protein independently of its RNA counterpart. Using two independent models to examine its specific functions, SRAP was found to enhance estrogen receptor alpha activity in a ligand and response-element dependent manner. Our data therefore suggest that both transcript and protein products of the SRA1 gene co-modulate the transcriptional activity of steroid receptors. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1174 / 1180

页数：7

共 27 条

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